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The main indication for oral antibiotics is moderate to severe inflammatory acne. Tetracyclines are the most commonly used family of antibiotics along with a class of antibiotics known as macrolides, and a third class called sulfonamides. Topical antibiotics and BP are indicated in people with mild to moderate inflammatory acne. Other antibacterial medications are sometimes prescribed to treat pimples, such as clindamycin, trimethoprim, and co-trimoxazole. However, the above top 4 antibiotics are the major motor behind the high success rate of antibacterial success in acne patients. Notes on taking prescription antibiotics.